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Sugar Promotes Breast Cancer

This is probably not surprising to most reading this blog, but here's another negative study for sugar, and more reason why you should minimize it as much as possible. What's interesting, however, is how the breast cancer "industry," while pretending to genuinely care about cancer prevention, actually promotes it. It's really incredible that these organizations use anything other than whole organic foods to raise funds. It's like selling cigarettes to raise funds for lung cancer research. In my opinion, at least fund-raise in a manner that doesn't promote what your fighting against. Common sense, right?

I remember a few years back writing a letter to the Princess Margaret Hospital (a leading cancer research institute in Toronto) during their annual charity lottery. My beef was that they had many gas-guzzling cars included in the lottery, at a time when we know how detrimental the burning of fossil fuels are to human health and cancer risk. Especially when hybrid vehicles were growing in popularity and electric vehicles were just getting a foothold in the market. Could they not run a lottery with prizes that support their mission? Surely I can't be the only one that questions their logic.

Anyway, enough of my thoughts...let's see what this new study had to say.

Apparently, this was the first study to investigate the direct effect of sugar consumption on the development of breast cancer using animal models. It also attempted to identify the mechanism(s) behind the sugar-cancer link.

Given that the per capita consumption of sugar in the U.S. has increased to over 45 kg (100 lbs) annually, recognising the links to breast cancer has become a significant public health issue. The increased consumption of sugary beverages has been identified as a significant contributor to an global epidemic of obesity, heart disease and cancer.

One mechanism this study looked at was whether the inflammatory cascade was in play for sugar-driven carcinogenesis. Four different studies were undertaken in which mice were randomised to different diet groups and fed one of four diets. At six months of age, 30% of mice on a starch-control diet had measurable tumours, whereas 50-58% of the mice on sucrose-enriched diets had developed mammary tumours.

The study also showed that numbers of lung metastases were significantly higher in mice on a sucrose- or a fructose-enriched diet, versus mice on a starch-control diet.

“We determined that fructose derived from the sucrose was responsible for facilitating lung metastasis and 12-HETE production in breast tumours,” the study stated. “Overall, our data suggested that dietary sugar induces 12-LOX signalling to increase risks of breast cancer development and metastasis.”

Previous studies have pinpointed the role of sugar, especially glucose, in energy-based metabolic pathways in cancer development. It has been well-documented that increased glucose flux and metabolism promotes several hallmarks of cancer such as excessive proliferation, anti-apoptotic signalling, cell cycle progression and angiogenesis.
I devote a large discussion on cancer in my book, in which I explain mitochondrial function plays a central role. I discuss the Warburg Effect, which is the observation that cancer cells shift metabolism to aerobic glycolysis, which requires lots of sugar (and therefore fresh blood vessels to deliver all that sweet debauchery). I also discuss the potential therapeutic role of diets like calorie restriction and especially ketogenic diets. So if your interested in this stuff, be sure to pick up a copy HERE.

Hope you have a happy Monday!

Source: A Sucrose-Enriched Diet Promotes Tumorigenesis in Mammary Gland in Part through the 12-Lipoxygenase Pathway

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