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Antidepressants With NSAIDs Linked to Brain Bleeding

Although antidepressants and NSAIDs (anti-inflammatory drugs) are each known to be associated with an increased risk for abnormal gastrointestinal bleeding, neither has been linked independently with an increased risk for bleeding in the brain. This newly published study looked to investigate this, and for this study, researchers analyzed data from the Korean nationwide health insurance database of 4,145,226 people who were treated with antidepressants with and without NSAIDs.

The main outcome measure was time to first hospital admission with intracranial haemorrhage within 30 days after drug use. Results found a 60% higher risk for bleeding in the brain during that 30-day period among patients treated with a combination of antidepressants and NSAIDs compared with those receiving antidepressants without NSAIDs.

There were no significant differences in the increased intracranial hemorrhage risk between the antidepressant classes of serotonin-norepinephrine reuptake inhibitors (SNRIs), selective serotonin reuptake inhibitors, or tricyclic antidepressants.

Why this is concerning is that about 65% of adults with major depression also have chronic pain. Not that intestinal bleeding and ulcers aren't a concern, but bleeding in the brain can be fatal if not identified and controlled.

So if you know someone taking both, make sure they know about this potential drug-drug interaction.

Click HERE to subscribe to Know Guff, and read the next study being posted on Friday (also on anti-depressants).

Source: Risk of intracranial haemorrhage in antidepressant users with concurrent use of non-steroidal anti-inflammatory drugs: nationwide propensity score matched study 

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