The main outcome measure was time to first hospital admission with intracranial haemorrhage within 30 days after drug use. Results found a 60% higher risk for bleeding in the brain during that 30-day period among patients treated with a combination of antidepressants and NSAIDs compared with those receiving antidepressants without NSAIDs.
There were no significant differences in the increased intracranial hemorrhage risk between the antidepressant classes of serotonin-norepinephrine reuptake inhibitors (SNRIs), selective serotonin reuptake inhibitors, or tricyclic antidepressants.
Why this is concerning is that about 65% of adults with major depression also have chronic pain. Not that intestinal bleeding and ulcers aren't a concern, but bleeding in the brain can be fatal if not identified and controlled.
So if you know someone taking both, make sure they know about this potential drug-drug interaction.
Click HERE to subscribe to Know Guff, and read the next study being posted on Friday (also on anti-depressants).
Source: Risk of intracranial haemorrhage in antidepressant users with concurrent use of non-steroidal anti-inflammatory drugs: nationwide propensity score matched study
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