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Vitamin B3 Rescues Failing Mitochondrial Function

A recent study found that only a single dose of a unique no-flush form of vitamin B3 (called nicotinamide riboside, or NR) may significantly increases levels of NAD+. For those who may not know the importance of NAD biology, I would suggest you read more about in my book, Life: The Epic Story of Our Mitochondria. In the meantime, you'll want to know that NAD+ is key to cellular energy metabolism and mitochondrial function.

This is the first study to show that NR supplementation can increase NAD+ in humans, which confirms the results seen in animal studies. What this means is that the benefits in animals seen with increased levels of NAD+ are highly likely to be seen in humans as well.

“As noted in numerous scientific studies, the potential health and therapeutic benefits of NR as a precursor to NAD+ are significant. The results of this clinical study should encourage more studies and research regarding the possible health benefits of NR in humans” said the lead researcher.

Mitochondrial dysfunction is increasingly implicated in diseases of ageing, autoimmune diseases, muscle wasting, neuropathies, obesity, and other conditions, and this study opens the door to the development of both consumer products and pharmaceuticals addressing these conditions.

As the mitochondria are the single greatest source of oxidative stress (free-radicals), the resulting dysfunction in the mitochondria has lead many researchers to examine if antioxidants such as CoQ10 may play a role. Another approach has been to raise levels of co-enzyme nicotinamide adenine dinucleotide (NAD+) in the mitochondria, which is an important cellular co-factor for improvement of mitochondrial performance and energy metabolism.

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Source: Yet to be published in a peer-reviewed journal (will update when published)

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  1. Thanks for the post. What dose did they use in this study?

    1. Hi Elisa. That's a great question, but unfortunately I don't know the answer at this point. Most NR products on the market currently recommend 250 mg per day, so I would guess this is a dose they looked at. However, the authors also point out that this was the first time an effective dosage "range" was determined for humans, so based on this, it would appear that numerous different doses were studied (a dose-finding study, so to speak).

      I'll post an update when I learn more myself (will likely need to wait until the manuscript is published). Stay healthy!


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