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K2´s Reversal of Arterial Calcification Finally Published

Well, I was hoping I could be more consistent in my posts this year, but with almost 3 weeks of work-related travel...well, that explains the 3 week gap since my last post. So let's pick things back up and feed that brain of yours with the "Know, L. edge."  :)

It's been almost 3 years now since I discussed the preliminary results of a study that suggested MK-7 (a form of vitamin K2) can reverse preexisting calcification in the arteries--considered by some to be the Holy Grail of cardiology. HERE is that study.

In that post, I mentioned I'd follow-up once the study was actually published since that was one of the only posts on this entire website that didn't have a corresponding reference. Well, it's finally been published in the medical journal Thrombosis and Haemostasis, and titled “Menaquinone-7 Supplementation Improves Arterial Stiffness in Healthy Postmenopausal Women.”

Here are the details:
  • 244 healthy post-menopausal women were randomly assigned to take 180 mcg/day of MK-7 for 3 years, or placebo capsules
  • 93% of the participants completed the 3-year study
  • Results confirm that MK-7 supplementation not only inhibits age-related stiffening of the artery walls, but also made a statistically significant improvement of vascular elasticity (again, implying a reversal of existing calcification).
“This is the first study showing that long-term use of vitamin K2 in the form of MK-7 beneficially affects cardiovascular health,” says Cees Vermeer, who led the study’s research team.

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Source: Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women: double-blind randomised clinical trial

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  1. Hi Dr. Know,

    Been reading your blog now for a few years--great service! Thanks!

    My question is this: I have been supplementing daily with 100mcg of Vitamin K-2 for a couple of years now. But I am a bit confused. On the Supplement Facts part of the label it states 'Vitamin K2 (as Menaquinone)--100mcg". Is this 'Menaquinone' the same as MK-7? I just assumed it was and it may not be. Can you clear this up for me before I order another bottle of same or should I switch over to a brand that clearly states 'MK-7' on the label? Many thanks!!!

    1. Hello,

      You may be the same one whose question I just answered in another post--and again, sorry for the delayed response. In this situation, I would follow-up with the manufacturer to determine whether the product is MK-4 or MK-7. "Menaquinone" is just an umbrella term denoting vitamin K2, but does not indicate which form of K2 it is. If you're looking for MK-7, it will say so on the ingredient list, or may also be disclosed as "menaquinone-7."

      Hope this helps.

  2. ..I like your article (I also like your book too). Few questions:

    1. While taking K2, one should stop calcium altogether? (Since there is abundance of calcium in your body due to calcification)
    2. Any K2 supplement will provide MK7 type of supplement
    3. Is K2 available as Ionic K2 and/or liquid Magnesium?
    4. IMHO, one should include Magnesium in the protocol with the K2

    1. Hi Max, and thank you for the positive feedback on the article and book. :)

      Here are your answers...

      1. In theory, as long as a person is consuming a healthy diet high in calcium, and as long as they are consuming enough K2, separate calcium supplements are likely not needed. However, it really depends on many factors, including their diet (could be low in calcium content), individual factors (malabsorption syndrome, celiac, etc.), so I hesitate to give a sweeping recommendation since it's best dealt on a case-by-case basis. Some people will not need calcium supplements, while others may be better off taking these.

      2. No. K2 in supplements can come as one of two forms: MK-4 and MK-7. You'll need to refer to a product's label to determine which form you're getting. (Keep in mind that vitamin K supplements can also come in the form of K1.)

      3. While vitamins can come in different forms, ionic is not one of them (to my knowledge). Minerals, on the other hand, can exist in a number of different ionic states (depending on the mineral), and this is what allows them to form salts and/or chelate to different molecules to form the types of products you typically find in a store as a supplement.

      4. Absolutely agree! Magnesium is essential in the healthy formation of bones and teeth, and used by the body for so many other reasons (including cellular energy production, as I mention in my book). Further, most people do not get enough of this essential mineral. This is further compounded by the fact that calcium and magnesium compete for absorption, so as people have increased their calcium intake (supplementally), it's suppressed the absorption of the little amount of magnesium that may be present in one's diet. Globally, magnesium has been the fastest growing mineral supplement (in sales), and IMO, that's for a good reason.

      Hope I've been able to address your questions adequately! Stay Healthy!



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