Thanks for visiting! My goal here is to discuss the latest scientific research to separate the good from all that "guff" in nutritional sciences and all aspects of human health. Because the more you Know, well...the more you Know!

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Let's Get Physical

We all know that a large chuck of the adult population isfar too sedentary, and research has shown that even modest amounts of physical activity can provide significant health benefits. Another study has similar results, but gives insight to how little is actually needed by sedentary adults.

The current guideline is 150 minutes or more of moderate activity each week (just over 20 minutes daily). Although the 150-minute goal is still ideal, the authors say, it may be a barrier to the most sedentary and to some older people. In fact, it may take far less than 150 minutes to achieve a significant reduction in mortality risk in sedentary people, they wrote.


Health Benefits of Hypoxia

We know that mitochondria utilize most of the oxygen we absorb from the air to produce ATP via oxidative phosphorylation (energy production that is coupled to the electron transport chain). Hypoxia (low oxygen levels) undoubtedly induces reduced energy production via decreased mitochondrial metabolic activity or altered mitochondrial biogenesis.


Statins Linked to Cataracts and Eye Surgery

Here's more reason to urge caution if looking to use statin medications to address high cholesterol levels. Analyses of two distinct cohorts, one from Canada and another from the US, both suggest that statin therapy significantly elevates the risk of developing cataracts (severe enough to warrant surgery). These studies add to growing list of studies that link this class of drugs to various health conditions, and the second post I've made on this specific connection (click HERE to read that one).


Alpha-Lipoic Acid Helps Restore Brain Metabolism

Here's a short post to end the week. This study examined the progress of a hypometabolic state (reduced energy production) inherent in brain aging with a rat model. Dynamic microPET scanning demonstrated a significant decline in brain glucose uptake at old ages, which was associated with a decrease in the expression of insulin-sensitive neuronal glucose transporters and of microvascular endothelium.


Avoiding Air Pollution for Cardiovascular Benefits

"Air pollution should be viewed as one of several major modifiable risk factors in the prevention and management of cardiovascular disease," contends a European Society of Cardiology (ESC) position paper published about a month ago.

The document primarily explores the mechanisms and relationships between ambient air pollution and CVD, but it ends with some advice on how physicians should counsel high-risk patients to minimize exposure to air pollution.
On detailing not only the main air pollutants that contribute to both short- and long-term mortality risk but also the mechanisms through which air pollutants contribute to different pathological processes, including inflammation and atherosclerosis, the authors emphasize that air pollution is not confined to the outdoors. Indeed, we know that many times indoor air quality is worse than the outdoors.

In a detailed "Societal and Personal Advice" section of the report, the panel focused on strategies aimed at reducing exposure to air pollution outdoors. For example, it said to:


Cannabis for Cancer Therapy

Well, here's a topic that's receiving so much more attention as medical marijuana becomes more widely acceptable and numerous States in the US have legalized recreational use (about time, IMO).

This new study suggests that cannabinoids may be useful as anticancer agents (just to be clear, this is not the first study to show this). According to the authors of this study, “Numerous reports highlighting potent activity in vitro and in in vivo models have established it as a potential anticancer therapeutic agent in a number of cancer types."


Metabolism and the Evolution of the Human Brain

Well, happy belated New Year! Hope it's started off on the right foot for everyone. For this blog, December was a slower month, as expected, but earlier this week, we had a record-breaking day with almost 2000 pageviews! So definitely off to a good start for traffic at this site--and thanks always to my subscribers and visitors for your support.

So to get things rolling again here, let's start with a study that looked at how a change in metabolism helped the human brain evolve, and this relates to mitochondrial energy production, ketogenesis, and the like, so read on!