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"Low" Doses May Be Effective for Vitamin K2 (as MK-4)

It's been a while since a new vitamin K study has been published. Now here is a study that suggests we can still get the bone benefits of MK-4 (a form of vitamin K2) at much lower doses than previously studied (which was about 45,000 mcg/day, and up to 60,000 mcg/day). For this new study, researchers recruited 15 healthy men (average age of 25) to participate in this newly published non-placebo controlled dose-finding study.

Osteocalcin (OC) is the vitamin K-dependent protein in bones that pulls calcium into the bones--it's essential for the body to utilize calcium in bone tissue. Without adequate vitamin K, the osteocalcin remains inactive (ucOC), and thus not effective. The ratio of ucOC to OC is a sensitive marker of bone’s vitamin K status

The men received daily MK-4 doses of 0, 300, 600, 900, and 1500 mcg for one week each in increasing order over five weeks. Results showed that activated OC levels were significantly increased at the dosages of 900 mcg/day or more. At 600 mcg/day, however, significant decreases in inactivated osteocalcin levels and the ratio of inactivated to activated osteocalcin were observed suggesting as low as 600 mcg/day is sufficient.

At least in Canada, this is still too high, unfortunately, to be legal for sale--where the max a product can recommend is 120 mcg/day. For this reason, I continue to believe that MK-7 is the ideal form and this study further backs my opinion. Peruse the other posts below to get a greater understanding of the forms of vitamin K and the various benefits of this fantastic vitamin.

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Source: Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose–response study

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