Osteocalcin (OC) is the vitamin K-dependent protein in bones that pulls calcium into the bones--it's essential for the body to utilize calcium in bone tissue. Without adequate vitamin K, the osteocalcin remains inactive (ucOC), and thus not effective. The ratio of ucOC to OC is a sensitive marker of bone’s vitamin K status
The men received daily MK-4 doses of 0, 300, 600, 900, and 1500 mcg for one week each in increasing order over five weeks. Results showed that activated OC levels were significantly increased at the dosages of 900 mcg/day or more. At 600 mcg/day, however, significant decreases in inactivated osteocalcin levels and the ratio of inactivated to activated osteocalcin were observed suggesting as low as 600 mcg/day is sufficient.
At least in Canada, this is still too high, unfortunately, to be legal for sale--where the max a product can recommend is 120 mcg/day. For this reason, I continue to believe that MK-7 is the ideal form and this study further backs my opinion. Peruse the other posts below to get a greater understanding of the forms of vitamin K and the various benefits of this fantastic vitamin.
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Source: Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose–response study
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