As you may have guessed from above, the topic of my book is mitochondrial health and cellular energetics. It's an incredibly fascinating area with a tonne of research being published every week. Seriously. I'm talking on average about 300 new peer-reviewed publications (every week) that are in one way or another connected to mitochondria. That's insane! Anyway, I think you'll hear MUCH more about the topic in the near future, so if you want to get your hands on a copy of the book and give yourself a head start in understanding this rapidly growing area, you can buy the book online through these various retailers:
- Zwell.ca - my exclusive online healthfood retailer for the softcover copy
- Amazon - where you can also purchase the Kindle ebook version
- Chapters/Indigo - where you can buy the Kobo ebook version
- many health food stores across Canada will soon stock the book in their literature section
I mention this since today's new study of discussion partly looked at the mitochondria, in relation to aluminum exposure. So, with that said, let's talk about this new study...
Aluminum (Al) is a ubiquitous substance encountered both naturally (as the third most abundant element) and intentionally (used in water, foods, pharmaceuticals, and vaccines); it is also present in ambient and occupational airborne particulates.
Existing data underscore the importance of Al physical and chemical forms in relation to its uptake, accumulation, and systemic bioavailability. The authors of the present review represents a systematic examination of the peer-reviewed literature on the adverse health effects of Al materials published since a previous critical evaluation compiled and published in 2007 . Challenges encountered in carrying out the present review reflected the experimental use of different physical and chemical Al forms, different routes of administration, and different target organs in relation to the magnitude, frequency, and duration of exposure.
Wide variations in diet can result in Al intakes that are often higher than the World Health Organization provisional tolerable weekly intake (PTWI), which is based on studies with Al citrate. Comparing daily dietary Al exposures on the basis of "total Al"assumes that gastrointestinal bioavailability for all dietary Al forms is equivalent to that for Al citrate, an approach that requires validation.
Current occupational exposure limits (OELs) for identical Al substances vary as much as 15-fold. The toxicity of different Al forms depends in large measure on their physical behavior and relative solubility in water. The toxicity of soluble Al forms depends upon the delivered dose of Al(+3) to target tissues. Trivalent Al reacts with water to produce bidentate superoxide coordination spheres that after complexation with O2(-), generate Al superoxides (free-radicals). Semireduced AlO2 radicals deplete mitochondrial Fe and promote generation of H2O2 and O2(-). Thus, it is the Al(+3)-induced formation of oxygen radicals that accounts for the oxidative damage that leads to intrinsic apoptosis. (Although there are controversies with Al exposure and risk of Alzheimer's disease (AD), knowing that mitochondrial dysfunction is now linked with this form of dementia, could point to Al-induced free-radicals as the bridge connecting Al exposure to AD.)
In contrast, the toxicity of the insoluble Al oxides depends primarily on their behavior as particulates. Aluminum has been held responsible for human morbidity and mortality, but there are too many data gaps and inconsistent results to make conclusions in many areas of health. Aluminum exposures during neonatal and pediatric parenteral nutrition (PN) can impair bone mineralization and delay neurological development. Adverse effects to vaccines with Al adjuvants have occurred; however, recent controlled trials found that the immunologic response to certain vaccines with Al adjuvants was no greater, and in some cases less than, that after identical vaccination without Al adjuvants.
The authors conclude that the scientific literature on the adverse health effects of Al is extensive. Health risk assessments for Al must take into account individual co-factors (e.g., age, renal function, diet, gastric pH). Finally, they point to the need for refinement of the PTWI, reduction of Al contamination in PN solutions, justification for routine addition of Al to vaccines, and harmonization of OELs for Al substances.
Click HERE to subscribe to Know Guff.
Source: Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts
- New Study: Organic vs. Conventional Foods
- Pesticide Linked to Alzheimer's Disease
- Neonicotinoids: Kills Bees and the Human Nervous System
- Artificial Blue Colours a Hazard to Children & Men
- Common Synthetic Antimicrobial Linked to Allergies in Children
- Phthalates Linked to Asthma in Children
- Cancer From "Safe" Levels of Herbicides & GM Corn
- More Evidence Confirms Pesticide-Diabetes Link