The study identified that when combined with a high caffeine intake (over 237.8 mg/day via coffee consumption), those with the CC-type variant of the GRIN2A gene saw a 47% reduction in PD risk. There was a dose-response curve and risk reduction increased to 58% with 200 - 400 mg of caffeine daily, 80% with 400 – 600 mg/day, and leveled off at 79% with more than 600 mg/day.
On the other hand, those with TC-type variant of the gene already had 47% reduced risk of PD, but there was no further reduction in risk from drinking coffee/caffeine.
The researchers state, “Caffeine integrates with a dopamine receptor that regulates the flow of calcium into the cell. As dopamine is part of the human reward system, and the interaction of caffeine with it, it has been speculated that individuals with certain genetic variations are not “rewarded” to the same extent by a cup of coffee, and therefore would not enjoy the same protective effect as others."
Click HERE to subscribe to Know Guff.
Source: Caffeine Interaction with Glutamate Receptor Gene GRIN2A: Parkinson's Disease in Swedish Population
Related coffee posts:
- Even Decaffeinated Coffee Protects Against Diabetes
- Coffee: Friend or Foe?
- Certain Foods in Mediterranean Diet Leads to Better Cognitive Function
- Coffee Speeds Recovery from Bowel Surgery
- Coffee Could Prevent Colon Cancer
- Coffee Can Help Prevent Alzheimer's Disease
- Coffee May Prevent Fatty Liver Fibrosis
- Coffee Polyphenols Benefit Post-Meal Sugar & Fat Metabolism
- Drink Coffee to Reduce the Risk of Prostate Cancer
- Coffee May Inhibit Some Breast Cancers
Related Parkinson's posts: