Docosahexaenoic acid (DHA) levels were significantly lower in blood and brains of aged mice which were raised by omega-3 administration. Isolated mitochondria from aged mice showed significantly
lower ATP (energy) levels and reduced activity of various component of the electron transport chain, which again improved with omega-3 administration.
However, APP fragments were largely unchanged after omega-3 treatment (in contrast to other previous studies that did show a positive change).
The findings provide new mechanisms underlying the neuroprotective actions of omega-3s and demonstrates its promise as a nutraceutical therapy to delay age-related mitochondrial dysfunction in the brain.
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Source: Omega-3 polyunsaturated fatty acids improve mitochondrial dysfunction in brain aging - Impact of Bcl-2 and NPD-1 like metabolites
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