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Omega-3s for Mitochondrial Function & Alzheimer's Prevention

Here is a quick post to discuss more reason to take your omega-3 supplements (krill oil, fish oil, etc.) This study investigated the effects of omega-3 fatty acids on mitochondrial function and processing of the amyloid precursor protein (APP) in brains of young and aged mice.

Docosahexaenoic acid (DHA) levels were significantly lower in blood and brains of aged mice which were raised by omega-3 administration. Isolated mitochondria from aged mice showed significantly
lower ATP (energy) levels and reduced activity of various component of the electron transport chain, which again improved with omega-3 administration.

However, APP fragments were largely unchanged after omega-3 treatment (in contrast to other previous studies that did show a positive change).

The findings provide new mechanisms underlying the neuroprotective actions of omega-3s and demonstrates its promise as a nutraceutical therapy to delay age-related mitochondrial dysfunction in the brain.

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Source: Omega-3 polyunsaturated fatty acids improve mitochondrial dysfunction in brain aging - Impact of Bcl-2 and NPD-1 like metabolites

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