This study involved pancreatic cancer cells, and high dose thiamine was found to reduce "cancer cell proliferation by a mechanism similar to that described for dichloroacetate" (DCA). Administration of thiamine was found to exhibit a lower IC50 value, as compared to DCA, and both thiamine and DCA reduced the extent of PDH phosphorylation, reduced glucose consumption, lactate production, and mitochondrial membrane potential, and increases caspase-3 activity.
Basically, this means that thiamine was effective at inhibiting the growth of pancreatic cancer cells.
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Source: High-dose vitamin B1 reduces proliferation incancer cell lines analogous to dichloroacetate
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