Thanks for visiting! My goal here is to discuss the latest scientific research to separate the good from all that "guff" in nutritional sciences and all aspects of human health. Because the more you Know, well...the more you Know!

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High Dose CoQ10 for Parkinson's Disease

For those familiar with the use of CoQ10 in Parkinson's Disease, or heard me discuss this during a seminar or presentation, you may remember that the dose for this neurological condition can go as high as 3000 mg per day! One published study even used 3600 mg daily. Comparatively, this study used lower doses, but still in line with most research in this area where the effective dose falls in the 1200-3000 mg/day range.


Vitamin D for Fibromyalgia

Here is a study that shows the potential value of vitamin D against fibromyalgia. In this placebo-controlled study involving 30 women with fibromyalgia, oral supplementation with cholecalciferol (vitamin D3) for 20 weeks was administered with a goal of achieving serum calcifediol between 32 and 48 ng/mL. 

Results found a marked reduction in pain over the treatment period in the group treated with vitamin D, and a significant group effect was found according to visual analog scale scores, which was correlated with scores on the physical role functioning scale of the SF-health survey 36.

Furthermore, "Optimization of calcifediol levels in fibromyalgia had a positive effect on the perception of pain."

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Source: Effects of vitamin D on patients with fibromyalgia syndrome: A randomized placebo-controlled trial

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Thiamine May Fight Pancreatic Cancer

Ok, so the next few posts are going to be short and sweet. This study was just an in vitro study, but I cover it here since we know the pharmacology/pharmacokinetics of thiamine (vitamin B1). This means it's a relatively smaller step to extrapolate these results to its potential benefit in humans.

This study involved pancreatic cancer cells, and high dose thiamine was found to reduce "cancer cell proliferation by a mechanism similar to that described for dichloroacetate" (DCA). Administration of thiamine was found to exhibit a lower IC50 value, as compared to DCA, and both thiamine and DCA reduced the extent of PDH phosphorylation, reduced glucose consumption, lactate production, and mitochondrial membrane potential, and increases caspase-3 activity.

Basically, this means that thiamine was effective at inhibiting the growth of pancreatic cancer cells.

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Source: High-dose vitamin B1 reduces proliferation incancer cell lines analogous to dichloroacetate

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Pesticide Linked to Alzheimer's Disease

Another study adds to the growing evidence that pesticide exposure is linked to adverse health consequences. This latest study now links a specific pesticide to a higher risk and increased severity of Alzheimer's disease.


Omega-3s Help Slow Brain Shrinkage in Elderly

This study reflects the results of another study I covered almost two years ago. In this new study, researchers analysed data from 1,111 women who were part of the Women's Health Initiative Memory Study. Levels of the omega-3 fatty acids, EPA and DHA, were measured in the women's red blood cells (RBC), and brain volumes were measured by MRI eight years later (when the women were an average age of 78).


Heart Patients' Memory Problems

Similar to THIS study I covered last year, another new study is confirming the link between a healthy heart and healthy brain--or more specifically, a bad heart and a bad brain.

In this new study, almost half of the 912 people in the study (with heart failure and who were at least 70 years old) had memory loss--but in most cases, their cardiologists failed to recognize the cognitive impairment.