This was a small pilot study that randomized 644 subjects (60-84 years of age) to receive one of three treatments:
- 60,000 IU/month vitamin D3 (an average of 2000 IU/day)
- 30,000 IU/month vitamin D3 (an average of 1000 IU/day)
- a placebo
Those given 60,000 IU/month were found to have a 28% lower risk of having antibiotics prescribed at least once during the 12-month study period (compared to the placebo group). When stratified for age, those 70 years of age or older were found to have a 47% reduction in antibiotic use in the high-dose vitamin D group, as compared with the placebo.
The authors conclude, "Although this study was a post hoc analysis and statistically nonsignificant, this trial lends some support to the hypothesis that supplementation with 60,000 IU vitamin D/mo is associated with lower risk of infection, particularly in older adults."
So this basically confirms what I said a couple days ago, that most evidence would point to 2000 IU/day as being the minimum dose needed to see an immune response for most.
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Source: Effect of vitamin D supplementation on antibiotic use: a randomized controlled trial
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