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Vitamin K2 Slows Progression of Arterial Calcification

Well, a second study on vitamin K in as many posts. This prospective, randomized study was designed to compare the effect of vitamin K2 plus low-dose vitamin D or vitamin D alone on the progression of coronary artery calcification score (CACS) and common carotid intima media thickness (CCA-IMT).

42 non-dialysis patients with chronic kidney disease (CKD) stage 3-5 and CACS≥10 Agatston units were randomized to one of two treatment arms: 
  1. K+D group received daily 90 μg vitamin K2 (as MK-7) plus 10 μg (400 IU) cholecalciferol (D3)
  2. D only group received 10 μg cholecalciferol
The study was about 9 months in length. CCA-IMT and CACS were measured at baseline and at the end of treatment. along with serum mineral parameters, lipids, 25-hydroxyvitamin D (25OHD) and calcification modulators: matrix Gla protein (MGP), osteoprotegerin (OPG), fetuin A, osteocalcin (OC) and fibroblast growth factor (FGF-23). 

To makes a long story short, vitamin K2 supplementation reduced the progression of CCA-IMT compared to those just taking vitamin D. The tendency of K2 to slow the progression of CACS was noticed to a greater extent in patients with less advanced vessel calcification at baseline.

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