42 non-dialysis patients with chronic kidney disease (CKD) stage 3-5 and CACS≥10 Agatston units were randomized to one of two treatment arms:
- K+D group received daily 90 μg vitamin K2 (as MK-7) plus 10 μg (400 IU) cholecalciferol (D3)
- D only group received 10 μg cholecalciferol
To makes a long story short, vitamin K2 supplementation reduced the progression of CCA-IMT compared to those just taking vitamin D. The tendency of K2 to slow the progression of CACS was noticed to a greater extent in patients with less advanced vessel calcification at baseline.
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