The study included 6967 statin users matched with 6967 nonusers. Of the statin users, the majority (73.5%) were treated with simvastatin, and approximately a third were prescribed the maximum dose of the drugs (although, in the US, Simvastatin at 80 mg/day is currently restricted due to concerns about muscle damage).
The analysis revealed that treatment with a statin was associated with a 19% increased risk of any type of musculoskeletal injury; a 13% increased risk of dislocations, strains, and sprains; and a 9% increased risk of musculoskeletal pain. There was a trend toward a higher risk (7%) of osteoarthritis/arthropathies, but was not statistically significant.
The researchers say that adverse musculoskeletal events may represent a lesser known side effect of the drug class and should be studied further, especially in individuals who continue to be physically active. These results are particular relevant to a younger age-group since statin therapy is being recommended at at younger and younger ages to prevent cardiovascular diseases--age groups that are likely to be highly physically active.
Source: Statins and Musculoskeletal Conditions, Arthropathies, and Injuries
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