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2013-06-14

B12 & Folate Reduce Risk of Macular Degeneration

I know you've got to get your weekend started, so I'll keep this one short. This study links homocysteine to yet another health condition, this time age-related macular degeneration (AMD).

This cohort study involved 1760 subjects who were 55 years and older. Results showed that elevated total serum homocysteine levels, folate deficiency, and vitamin B12 deficiency were all found to predict increased risk of AMD.


Each standard deviation (a statistical concept) increase in total serum homocysteine was associated with a 33% increase in AMD incidence. Vitamin B-12 deficiency was linked to 58% higher incidence of early AMD and a 156% increased incidence of late AMD. Folate deficiency was associated with 75% and 89% increased incidence of early and any AMD, respectively.

However, subjects who supplemented with vitamin B12 had a 47% reduced risk of incident any AMD. These results suggest that supplementation with vitamin B12 and folate (and I'd add B6) may reduce the risk of AMD.

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