The first study was a systematic review on intermittent claudication, which analyzed the results of 17 studies (8 parallel randomized controlled trials, 5 crossover RCTs, 5 pre-test/post-test trials). Results revealed that a small or moderate improvement in walking performance was found to be associated with supplementation with L-carnitine in patients.
As compared to placebo, pain-free walking distance and maximal walking distance improved by 23-132 m and 104 m, respectively, following L-carnitine supplementation. Some evidence indicated more significant benefits in patients with severe claudication versus moderate claudication.
Source: A systematic review to evaluate the effectiveness of carnitine supplementation in improving walking performance among individuals with intermittent claudication
The second study involved 118 healthy women with a singleton term pregnancy (at least 37 weeks). The researchers found significantly higher serum L-carnitine levels in women with pre-pregnancy BMI of less than 18.5 kg/m2 (normal), while those with BMI greater than 29.9 kg/m2 (obese) were found to have significantly lower serum carnitine levels.
Furthermore, the lower the total serum L-carnitine levels were, the higher pre-pregnancy body weight and BMI, pregnancy body weight and BMI, and serum triglyceride levels. On the other hand, the higher the total serum L-carnitine levels, the higher HDL cholesterol (the "good" cholesterol) levels.
The authors conclude, "The crucial role of L-carnitine in pregnancy metabolism suggests that nutritional supplementation of this amino acid can be offered to women who are either overweight or obese at the beginning of the pregnancy."
Source: Lowered serum total L-carnitine levels are associated with obesity at term pregnancy
Click HERE to subscribe to Know Guff by email
- L-Carnitine Linked to Clogged Arteries?
- Does L-Carnitine Help with Weight Loss?
- L-Carnitine Improves Behaviour in Autistic Kids
- L-Carnitine May Help Kids with Asthma
- L-Carnitine May Reduce Oxidative Damage
- L-Carnitine Helps Treat Autism Spectrum Disorders
- L-Carnitine May Protect Mitochondrial Function in Liver
- L-Carnitine Benefits Huntington's Disease
- L-Carnitine May Reduce Inflammation in Hemodialysis Patients
- Advantages of L-carnitine in Treating Hepatitis C