The first study I'll cover was a randomized, double-blind, placebo-controlled study involving 20 patients with fibromyalgia. Supplementation with 300 mg/day CoQ10 for 40 days was found to be associated with clinical improvements, including a prominent reduction in pain, fatigue, and morning tiredness.
There was also a reduction in tender points, and recovery of inflammation, antioxidant enzymes, mitochondrial biogenesis and AMPK gene expression levels (AMPK is an important enzyme in cellular energy metabolism). These results lead to the hypothesis that CoQ10 have a potential therapeutic effect in fibromyalgia and indicate new potential molecular targets for the therapy of this disease.
Source: Can Coenzyme Q10 improve clinical and molecular parameter in Fibromyalgia?
The second study was another small one involving 10 subjects with juvenile fibromyalgia (FM) and 67 healthy controls. Plasma levels of ubiquinol (reduced form of CoQ10) were significantly decreased and the ratio of ubiquinone (oxidized CoQ10) to total CoQ10 was significantly increased in juvenile FM patients (when compared to the healthy controls). This suggested that FM is associated with CoQ10 deficiency and increased oxidative stress.
The patients were then supplemented with 100 mg daily of ubiquinol, the reduced form of CoQ10 that's showing to be much more effective than standard CoQ10 supplements. 12 weeks of ubiquinol use was found to be associated with significant improvements in chronic fatigue scores, increases in CoQ10 levels, decreases in the ubiquinone to total CoQ10 ratio. Again, these results suggest that CoQ10 status may be impaired in subjects with juvenile FM and supplementation may be of benefit to such patients.
Source: Increased oxidative stress and coenzyme Q10 deficiency in juvenile fibromyalgia: amelioration of hypercholesterolemia and fatigue by ubiquinol-10 supplementation
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