Macrophages are responsible for eating-up amyloid beta and other waste products in the brain and body. The team incubated the macrophages with amyloid-beta and added either an active form of vitamin D3 (1alpha,25–dihydroxyvitamin D3) or an active form of the omega-3 fatty acid DHA (resolvin D1) to some of the cells to gauge the effect they had on inflammation and amyloid beta absorption.
In the AD patients' macrophages, both compounds were found to improve the ability of these immune cells to break-down amyloid beta, and both inhibited the cell death that usually result from these plaques.
While this study found amazing potential with the respective biologically active forms of these common nutrients, they are unavailable as supplements at this time. The next best thing is to get DHA (an omega-3) and vitamin D3, and let your body convert them to these powerful and bioactive metabolites.
Source: 1α,25-Dihydroxyvitamin D3 and Resolvin D1 Retune the Balance between Amyloid-β Phagocytosis and Inflammation in Alzheimer's Disease Patients
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