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2013-01-14

Will Ubiquinol Slow the Progression of ALS?

Coenzyme Q10 (CoQ10) appears to be a promising agent in neurodegenerative disorders because they are associated with defects in oxidative phosphorylation. Today, I'm covering a published case report, where the aim was to highlight the role of CoQ10 in amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease).

The case centred around a 75-year old medical scientist who presented with weakness of left leg along with cramps in the left calf muscle with steppage gate in September 2000. He had wasting of muscles, fasciculations and exaggerated reflexes. He had rapid deterioration in hand grip power in the left hand and weakness in left lower limb followed by right limbs with inability in walking and routine activities.

He volunteered for treatment with CoQ10 administration, and self-recorded his symptoms, mood, sensations, body weight, using limb Norris score, hand grip power for both hands. He received a highly bioavailable CoQ10 product (as solubilized ubiquinol, marketed in Canada as Inno-Q-Nol UltraSorb) in a dose of 500 mg twice daily initially followed by 200mg twice daily for treatment in 2005.

Treatment with solubilized ubiquinol (in 2005) resulted in better hand grip power, mood and sensation within a month and in 2006, he reported that hand grip power and wasting of muscles are not progressing as rapidly as before administering CoQ10.

This case report suggests treatment with solubilized ubiquinol can provide benefit to patients with ALS, and further studies in the form of randomized, controlled trials may help confirm these findings.

Source: Effects of Coenzyme Q10 Administration in Amyotrophic Lateral Sclerosis (ALS). Report of a Case and Review

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