In a controlled study involving 77 patients with coronary artery disease (CAD) and 44 healthy controls, found that antioxidant balance and oxidative stress in DNA may play an important role in the pathogenesis of CAD. The comparative ratios of ubiquinol/ubiquinone, as well as couple markers of oxidative stress were measured.
Oxidative stress was was elevated in CAD patients
compared to controls. The ubiquinol/ubiquinone ratio was lower in patients
with CAD than controls (indicating lower than desired ubiquinol concentrations).
Findings suggest that the disruption of pro-oxidant/antioxidant balance and
oxidative stress in DNA may play an important role in CAD (probably not anything "new," but confirms what we already knew, or at least thought).
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Source: Correlations between Oxidative DNA Damage, Oxidative Stress and Coenzyme Q10 in Patients with Coronary Artery Disease
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