Results indicated that MK-7 was well absorbed and was measurable in serum samples up to 2 days after consumption. On the flipside, however, MK-4 was not measured in any of the women at any time, the researchers said.
A second study used multiple daily 60 mcg doses of MK-4 or MK-7 for seven days. Again, the results indicated that MK-4 did not increase MK-4 levels. On the other hand, MK-7 was found to increase MK-7 levels.
“The current study shows that MK-4 has a poor bioavailability at a nutritional level dose, whereas MK-7 is well absorbed and detectable in the blood at nutritional levels,” wrote the researchers.
“In a previous rat study from our group, the intake of a nutritional dose of MK- 4 did not increase the MK-4 levels in extrahepatic tissues, whereas MK-7 significantly increased MK-4 in extrahepatic tissues,” they added.
This is very promising news, especially for us Canadians, where the dominant form of K2 in supplements is MK-7.
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Source: Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women
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