This randomized, double-blind, placebo-controlled study study found dietary fish oil supplementation for 6 months may have effects on expression of genes which influence AD.
Baseline expressions of approximately 8000 genes were assessed by gene array. After 6 months, the omega-3 fatty acid group displayed up-regulation of nine genes, and down-regulation of ten genes, which correspond to regulation of inflammation and neurodegeneration. Results suggest that 6 months of dietary omega-3 fatty acid supplementation may affect expression of genes that might influence inflammatory processes and could be of significance for AD patients.
This may be "upstream" to the previous study on beta-amyloid, as I would hazard to guess that beta-amyloid formation would be a result of inflammation. Either way, it's great to see our understanding of this horrible disease deepen.
Source: Effects of DHA- Rich omega-3 Fatty Acid Supplementation on Gene Expression in Blood Mononuclear Leukocytes: The OmegAD Study
Other posts on Alzheimer's and dementia:
- Omega-3s for Alzheimer's Disease Prevention
- Vitamin D3 Helps Clear Amyloid in Alzheimer's Disease
- CoQ10 a Potential Therapy for Alzheimer's Disease
- Nutrition for Alzheimer’s and Dementia
- Coffee and a Healthy Diet May Protect Against Alzheimer’s Disease
- Arterial Calcification Linked to Dementia
- Omega-3s for Dysmenorrhea
- Omega-3s During Pregnancy Reduces Kids' Eczema and Egg Allergy Risk
- Omega-3 Fatty Acids May Repair Nerve Damage
- Omega-3s Prevent Ventricular Arrhythmias & Heart Attacks
- Low Omega-3s Linked to Children with ADHD and Learning Difficulties
- Omega-3s Keep the Brain Young
- Omega-3s for Atrial Fibrillation
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