Thanks for visiting! My goal here is to discuss the latest scientific research to separate the good from all that "guff" in nutritional sciences and all aspects of human health. Because the more you Know, well...the more you Know!

Looking for a specific post? You can browse the Most Read Posts, the Blog Archives, or use the Search function in top left of this page. Thanks for your support and stay healthy!

Monthly 3D Poll


Vitamin D3 Helps Clear Amyloid in Alzheimer's Disease

Another study shows the benefits of vitamin D3 to cognitive health. This time, a team of researchers has uncovered how vitamin D3 may help clear amyloid-beta from the brain, the hallmark of Alzheimer's disease (AD). The study also adds more evidence that adequate levels of vitamin D may be a key factor in AD prevention.

In an interview, the researchers state, "the clinical implications are that vitamin D3 protects the brain through the immune system and that recommended blood levels of the 25-hydroxy vitamin D3 should be maintained in all seasons including winter when the sun is not helping to produce vitamin D in the skin."

Brain clearance of amyloid-beta 1-42 (Aβ-42) by innate immune macrophages (a type of white blood cell, called microglial cell when found in the central nervous system) is required for maintenance of normal brain function. This process of phagocytosis (the process where one cell engulfs/eats something) is defective in AD patients.

In their latest laboratory studies, the research team isolated macrophages from blood samples taken from patients with AD and healthy controls. They incubated the cells overnight with amyloid-beta, some in the presence of vitamin D3 and/or curcuminoids.

The researchers observed that vitamin D3 activates a specific chloride channel that is important in the clearance of Aβ-42 in both types of AD macrophages (type I and type II).

It appears from this work that vitamin D3 can "retune AD macrophages to efficiently phagocytose soluble Aβ-42 by regulating the function of both extranuclear proteins (ie, nongenomic signaling) and expression of genes (genomic signaling)," the researchers report.

Source: Genomic and Nongenomic Signaling Induced by 1α,25(OH)2-Vitamin D3 Promotes the Recovery of Amyloid-β Phagocytosis by Alzheimer's Disease Macrophages

Other posts on Alzheimer's and dementia:
Other posts on vitamin D:

Click HERE to subscribe to Know Guff by email


  1. Nice healthy information you have shared on Vitamin D to prevent Alzheimer's disease. Thank you for your healthy support.

  2. Please there is a cure for dementia and no one knows. This is my husband’s story... My husband was a retired force man, he had partial stroke 5 years ago, and then i was still working. His condition got worse and he was hospitalized. After some time of treatment he began to behave abnormal, like someone who has lost memory of event and occurrence. i shared tears the very day i walked to him in the hospital and he could not even recognize me. This is am man that is very playful and highly romantic. Each day i hold him to myself and share tears the more. He was not able to do anything just look at me like a bull dog and do so many abnormal things. Later on doctor brought a recent report and he was diagnosed of dementia this doctor says have no cure that he would die a brainless man. Oh my God i fainted when i heard this. I raised my voice and cry to God to help me from this. So i began to hope and trust God to do miracle. My pastor was a great pillar of encouragement to me. i did all i can to get a cure for him, but none worked out, i spent thousands of USD trying to get a cure for him. But behold a friends doctor came visiting and said to me let’s look if herbal remedy can help him get any better so he gave me your website which is www. Drisimhenmhenherbalhome.com there i saw how people testified of the good works of herbs in their life, so i decided to contact the doctor because his contact details was on his website.. The first time i emailed him, i got no reply from him, so i decided to call him on the phone. I called him, and told him what he could do was to laugh and said to me that anything the enemy have planned against my husband must fail, he said to me that he have cured Alzheimer's Disease and this is exactly what my husband is suffering from. After all, he prepared herbs and sent to me, i have to force my husband to take it because before then he was not taking anything from me to eat anymore. but behold sir it was just like a magic gradually my husband begin to get better, better and today sir i am proud to say my husband is totally cured, He you cured my husband of this deadly dementia disease and now i keep my promise i made to him before the cure that i will let the entire world know about his herbs if my husband is cured. Sir, now i am overwhelmed. God bless you sir. My husband has the plans to travel to see the doctor facially and say a physical thanks to him in his country, and i will accompany him down to his home in his country to also show my gratitude him. God bless him in abundant. If you have same problem or have other health issues and want to contact Doctor Isimhenmhen Anthony, here is his website (http://drisimhenmhenherbalhome.com)


Please use your name or alias. Due to a large volume of spam comments (as "Anonymous") all comments from "Anonymous" will be automatically deleted. Thanks.