In a randomized, placebo-controlled study involving 38 outpatients with type 2 diabetes mellitus (DM), supplementation with alpha-lipoic acid (300, 600, 900, and 1200 mg/d) for a period of 6 months was found to be associated with reductions in fasting blood glucose and HbA1c in a dose-dependent manner. Furthermore, other markers suggest ALA may suppressed lipid oxidation.
The authors conclude, "Results from this study reflected the benefits of ALA in glucose status with slight efficiency on oxidative stress-related deterioration in DM patients."
Source: Glycemic and oxidative status of patients with type 2 diabetes mellitus following oral administration of alpha-lipoic acid: a randomized double-blinded placebo-controlled study
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