A new "common-sense study" solidifies the association of long-term use of proton pump inhibitors (PPIs) with increased risk for hip fracture in postmenopausal women, particularly those who smoke.
PPIs can affect fracture risk by various mechanisms: increasing gastrin secretion,
inhibiting calcium absorption, and altering osteoclast function. These drugs are extensively used to treat acid reflux--usually inappropriately.
The study found that hip fracture risk increased the longer a person was taking PPIs. Compared with
non-users, there was a 36% higher risk for women using a PPI for two years, 42% higher risk for
four years' use, and 55% higher risk for six to eight years' use. However, the risk returns to normal for women
who have ceased taking the drugs for at least 2 years.
Smoking history stood out among the risk factors considered. Fracture
risk rose by about 51% for women who currently smoke or did so
previously. The researchers suggests that smoking inhibits calcium
absorption and this may act synergistically with PPIs to increase
Just over a month ago, I covered another study the linked PPIs to pneumonia. You can click HERE to read that post.
Source: Use of proton pump inhibitors and risk of hip fracture in relation to dietary and lifestyle factors: a prospective cohort study
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