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2012-02-08

Proton Pump Inhibitors Increase Risk of Hip Fractures

A new "common-sense study" solidifies the association of long-term use of proton pump inhibitors (PPIs) with increased risk for hip fracture in postmenopausal women, particularly those who smoke.

PPIs can affect fracture risk by various mechanisms: increasing gastrin secretion, inhibiting calcium absorption, and altering osteoclast function. These drugs are extensively used to treat acid reflux--usually inappropriately.

The study found that hip fracture risk increased the longer a person was taking PPIs. Compared with non-users, there was a 36% higher risk for women using a PPI for two years, 42% higher risk for four years' use, and 55% higher risk for six to eight years' use. However, the risk returns to normal for women who have ceased taking the drugs for at least 2 years.

Smoking history stood out among the risk factors considered. Fracture risk rose by about 51% for women who currently smoke or did so previously. The researchers suggests that smoking inhibits calcium absorption and this may act synergistically with PPIs to increase fracture risk

Just over a month ago, I covered another study the linked PPIs to pneumonia. You can click HERE to read that post.

Source: Use of proton pump inhibitors and risk of hip fracture in relation to dietary and lifestyle factors: a prospective cohort study

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1 comment:

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    ReplyDelete

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