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2012-02-10

Low-Dose K2 (as MK-7) Proven to be Effective

Vitamin K is required for the activation of "Gla-proteins" in the liver (coagulation factors) and extra-hepatic tissues, such as bone (osteocalcin, OC), and arterial wall (matrix Gla-protein, MGP). Although the coagulation factors are essentially fully carboxylated (activated) under normal conditions, 10-40 % of OC and MGP remains undercarboxylated (inactive).

The researchers of this study, therefore, were interested in studying the dose-response effects of extra intake of vitamin K2 on the carboxylation of these extra-hepatic vitamin K-dependent proteins. A total of 42 healthy Dutch men and women aged between 18 and 45 years were randomised into seven groups to receive: placebo capsules or menaquinone-7 (MK-7) capsules at a dose of 10, 20, 45, 90, 180 or 360 μg/day. Circulating uncarboxylated OC (ucOC), carboxylated OC (OC) and desphospho-uncarboxylated MGP (ucMGP) were measured.

Since this was a small study with few participants, in order to increase the statistical power, the researchers collapsed the treatment groups into three dosage groups: placebo, low-dose supplementation (doses below RDA), and high-dose supplementation (doses around RDA).

Results showed that MK-7 supplementation at relatively low doses in the order of the RDA increased the carboxylation of circulating OC and MGP. No adverse effects on thrombin generation (blood clotting) were observed.

Source: Low-dose menaquinone-7 supplementation improved extra-hepatic vitamin K status, but had no effect on thrombin generation in healthy subjects

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3 comments:

  1. I like your new ad on raspberry ketones...quite appropriate. I don't stock this, but had many people asking for it after Dr. Oz recommended it. I was like, huh?
    It's amazing how much influence a doctor who has no training in clinical nutrition has on the general public.

    ReplyDelete
    Replies
    1. Exactly why I created that ad. Isn't it nice to know that a "guru" is recommending you take something that has NO human clinical data?!

      From your comment, I gather you're a healthfood store owner/employee, and while I hear that he does a great job at driving traffic to the stores, he often comes close to damaging the industry and stripping it of its credibility. (I don't watch his show--nor do I watch much TV, period--but I do hear about it frequently.)

      However, not everything he's talked about is bunk. I know he's previously covered numerous natural substances that do have good human clinical evidence. So I guess, you just have to be selective in internalizing what he says or recommends.

      Delete
  2. I’m not that much of a online reader to be honest but your sites really nice, keep it up!

    I'll go ahead and bookmark your site to come back in the future. Many thanks

    ReplyDelete

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