Vitamin K is required for the activation of "Gla-proteins" in the liver
(coagulation factors) and extra-hepatic tissues, such as bone (osteocalcin, OC),
and arterial wall (matrix Gla-protein, MGP). Although the coagulation factors
are essentially fully carboxylated (activated) under normal conditions, 10-40 % of OC and
MGP remains undercarboxylated (inactive).
The researchers of this study, therefore, were interested in studying the dose-response effects of extra intake of vitamin K2 on the carboxylation of these extra-hepatic vitamin K-dependent proteins. A total of 42 healthy Dutch men and women aged between 18 and 45 years were randomised into seven groups to receive: placebo capsules or menaquinone-7 (MK-7) capsules at a dose of 10, 20, 45, 90, 180 or 360 μg/day. Circulating uncarboxylated OC (ucOC), carboxylated OC (OC) and desphospho-uncarboxylated MGP (ucMGP) were measured.
Since this was a small study with few participants, in order to increase the statistical power, the researchers collapsed the treatment groups into three dosage groups: placebo, low-dose supplementation (doses below RDA), and high-dose supplementation (doses around RDA).
Results showed that MK-7 supplementation at relatively low doses in the order of the RDA increased the carboxylation of circulating OC and MGP. No adverse effects on thrombin generation (blood clotting) were observed.
The researchers of this study, therefore, were interested in studying the dose-response effects of extra intake of vitamin K2 on the carboxylation of these extra-hepatic vitamin K-dependent proteins. A total of 42 healthy Dutch men and women aged between 18 and 45 years were randomised into seven groups to receive: placebo capsules or menaquinone-7 (MK-7) capsules at a dose of 10, 20, 45, 90, 180 or 360 μg/day. Circulating uncarboxylated OC (ucOC), carboxylated OC (OC) and desphospho-uncarboxylated MGP (ucMGP) were measured.
Since this was a small study with few participants, in order to increase the statistical power, the researchers collapsed the treatment groups into three dosage groups: placebo, low-dose supplementation (doses below RDA), and high-dose supplementation (doses around RDA).
Results showed that MK-7 supplementation at relatively low doses in the order of the RDA increased the carboxylation of circulating OC and MGP. No adverse effects on thrombin generation (blood clotting) were observed.
Source: Low-dose menaquinone-7 supplementation improved extra-hepatic vitamin K status, but had no effect on thrombin generation in healthy subjects
Related posts:
- Human Study Suggests Vitamin K2 (as MK-7) REVERSES Arterial Calcification
- Do Calcium Supplements Cause Heart Attacks?
- Warfarin, Vitamin K, and Heart Attacks from Calcium
- Calcium & Vitamin D Linked to Kidney Stones -- More Reason for Vitamin K?
- Vitamin K Improves Bone Mineral Density
- Vitamin K Deficiency Linked to Inflammatory Bowel Diseases
- Vitamin K May Improve Cognitive Health in the Elderly
- Arterial Calcification Linked to Dementia
- Administration of Oral Vitamin K2 to Newborns
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I like your new ad on raspberry ketones...quite appropriate. I don't stock this, but had many people asking for it after Dr. Oz recommended it. I was like, huh?
ReplyDeleteIt's amazing how much influence a doctor who has no training in clinical nutrition has on the general public.
Exactly why I created that ad. Isn't it nice to know that a "guru" is recommending you take something that has NO human clinical data?!
DeleteFrom your comment, I gather you're a healthfood store owner/employee, and while I hear that he does a great job at driving traffic to the stores, he often comes close to damaging the industry and stripping it of its credibility. (I don't watch his show--nor do I watch much TV, period--but I do hear about it frequently.)
However, not everything he's talked about is bunk. I know he's previously covered numerous natural substances that do have good human clinical evidence. So I guess, you just have to be selective in internalizing what he says or recommends.
I’m not that much of a online reader to be honest but your sites really nice, keep it up!
ReplyDeleteI'll go ahead and bookmark your site to come back in the future. Many thanks