BuChE activity and malondialdehyde (MDA, a marker of oxidative stress) were measured in plasma of all subjects. The control group comprised of untreated patients at diagnosis, the treatment group received treatment with protein restriction and L-carnitne supplementation.
Researchers verified a reduction of BuChE activity as well as an increased MDA formation in the plasma of untreated patients.
Treated patients presented MDA and BuChE activity similar to controls. In these patients, BuChE activity was negatively correlated with MDA concentrations.
These results suggest that treatment with L-carnitine (and low-protein diet) may prevent this BuChE-related free-radical damage.
Source: Reduction of butyrylcholinesterase activity in plasma from patients with disorders of propionate metabolism is prevented by treatment with L-carnitine and protein restriction
To review the other posts on L-carnitine:
- protecting mitochondrial function in the liver
- its use in treating patients with hepatitis C
- for autism spectrum disorders
- L-carnitine may reduce inflammation in hemodialysis patients
- L-carnitine may help kids with asthma
- L-carnitine benefits Huntington's Disease
Correction (posted 2011-12-22): My mistake...today (Dec 22) is winter solstice. So tonight, I celebrate again.
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