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2011-12-21

L-Carnitine May Reduce Oxidative Damage

So here's a study on L-carnitine for a condition that's a little more obscure than the typical health conditions I discuss, but I include it here to illustrate the breadth of therapeutic benefits of this amino acid. In this study, researchers investigated the relationship between butyrylcholinesterase (BuChE) activity and lipid oxidative damage in patients with disorders of propionate metabolism, before and after treatment with protein restriction and L-carnitine.

BuChE activity and malondialdehyde (MDA, a marker of oxidative stress) were measured in plasma of all subjects. The control group comprised of untreated patients at diagnosis, the treatment group received treatment with protein restriction and L-carnitne supplementation.

Researchers verified a reduction of BuChE activity as well as an increased MDA formation in the plasma of untreated patients.

Treated patients presented MDA and BuChE activity similar to controls. In these patients, BuChE activity was negatively correlated with MDA concentrations.

These results suggest that treatment with L-carnitine (and low-protein diet) may prevent this BuChE-related free-radical damage.

Source: Reduction of butyrylcholinesterase activity in plasma from patients with disorders of propionate metabolism is prevented by treatment with L-carnitine and protein restriction

To review the other posts on L-carnitine:

So BTW, today is winter solstice--the darkest day of the year for us in the Northern hemisphere. This means from this point on, for the next 6 months, the days are just going to get brighter and brighter. I'll take that as a reason to celebrate. Well, if you know me, you'll know I use any excuse to celebrate.  ;)

Correction (posted 2011-12-22): My mistake...today (Dec 22) is winter solstice. So tonight, I celebrate again.

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