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Diabetic Drug Increases Risk of Bladder Cancer

Here's a short "guff" post to start the month of December...

Pioglitazone is a drug indicated in multiple clinical settings as an adjunct to diet and exercise to improve blood sugar control in adults with type 2 diabetes.

A recent US FDA safety review suggests that use of pioglitazone for more than 12 months is associated with an increased risk for bladder cancer. Observational studies and a review by the European Medicines Agency (EMA) have supported this conclusion.

The labels have now been updated to state that pioglitazone should not be started in patients with active bladder cancer and should be used with caution in patients with a prior history of bladder cancer.

Further, the new labels state that patients should contact their doctors if they either experience blood or see a red color in their urine. Patients should also be aware of other symptoms that might be due to bladder cancer, including new or worsening urinary urgency or pain on urination since starting pioglitazone.

Source: FDA Drug Safety Communication: Updated drug labels for pioglitazone-containing medicines

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