In addition, most prospective studies have shown a significant inverse association of baseline serum 25(OH)D with incident diabetes -- meaning lower the vitamin D levels, the higher the risk of type 2 diabetes. To date, however, the exact mechanisms through which vitamin D affects diabetes risk are not yet fully known, particularly whether vitamin D plays a role in insulin resistance and/or β-cell dysfunction, the main pathophysiological disorders underlying type 2 diabetes.
Therefore, this new study looked at β-cell function to determine whether this is the potential mechanism of action for vitamin D in diabetes.
What this study saw was that higher baseline 25(OH)D independently predicted better β-cell function and lower blood glucose at follow-up, supporting a potential role for vitamin D in the prevention of type 2 diabetes.
This backs-up a couple other studies I had covered previously:
Source: Prospective Associations of Vitamin D With β-Cell Function and Glycemia: The PROspective Metabolism and ISlet cell Evaluation (PROMISE) Cohort Study
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