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Coffee Polyphenols Benefit Post-Meal Sugar & Fat Metabolism

Postprandial (the time period after a meal) energy metabolism, including postprandial hyperglycaemia, hyperinsulinaemia and hyperlipidaemia (the increase in blood sugar, insulin, and fats after eating) is related to the risk for developing obesity and cardiovascular disease.
This new animal study on coffee examined the effects of coffee polyphenols (CPP) on postprandial carbohydrate and lipid metabolism, and whole-body oxidation.

In mice that co-ingested CPP with a lipid–carbohydrate (sucrose or starch)-mixed emulsion, the respiratory quotient determined by indirect calorimetry was significantly lower than that in control mice, whereas there was no difference in VO2 (energy expenditure), indicating that CPP modulates postprandial energy partitioning. CPP also suppressed postprandial increases in plasma glucose, insulin, glucose-dependent insulinotropic polypeptide and triglyceride levels.

Inhibition experiments on digestive enzymes revealed that CPP inhibits maltase and sucrase, and, to a lesser extent, pancreatic lipase in a concentration-dependent manner.

These results suggest that CPP modulates whole-body substrate oxidation by suppressing postprandial hyperglycaemia and hyperinsulinaemia, and these effects are mediated by inhibiting digestive enzymes.

Source: Coffee polyphenols modulate whole-body substrate oxidation and suppress postprandial hyperglycaemia, hyperinsulinaemia and hyperlipidaemia

As the regular readers or subscribers know, I've covered a number of coffee studies in the last few months. For further reading, here are some other studies I've covered on coffee:
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  1. I just subscribed to your updates yesterday, I like your blog, thank you for sharing.
    Does the benefit come from drinking coffee just after a meal, or can morning coffe help with meals later in the day also?
    If it's best to have it after a meal, does decaf have the same effect?
    I love coffee and an excuse to have it after dinner would be nice, but I can't have caffeinated coffee after 2 pm without it impacting my sleep.
    Thanks again,

  2. Thanks Tamara for signing up! Now, I'm by no means an expert on coffee--although I love it myself--but it would seem that you'd need to drink it with your food to get the metabolic benefits outlined in this post (probably doesn't matter when you drink it to get the other benefits discussed in the other posts).

    Also, doesn't seem like caffeine is the compound responsible for the metabolic benefits, although I can't say for sure. This particular study specifically referred to coffee polyphenols, but the question is whether these polyphenols would be removed in the decaffeinating process or not. The other thing to consider is whether there is a synergistic effect with caffeine and these polyphenols (in other words, does decaf coffee have the same effects as this study suggests even if the polyphenols are present, or do you need caffeine present to realize the health benefits of these polyphenols?). I don't have answers to these questions...yet. But I'll keep looking for other studies that may shed some light on the subject.

    Stay healthy!



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