This new animal study on coffee examined the effects of coffee polyphenols (CPP) on postprandial carbohydrate and lipid metabolism, and whole-body oxidation.
In mice that co-ingested CPP with a lipid–carbohydrate (sucrose or starch)-mixed emulsion, the respiratory quotient determined by indirect calorimetry was significantly lower than that in control mice, whereas there was no difference in VO2 (energy expenditure), indicating that CPP modulates postprandial energy partitioning. CPP also suppressed postprandial increases in plasma glucose, insulin, glucose-dependent insulinotropic polypeptide and triglyceride levels.
Inhibition experiments on digestive enzymes revealed that CPP inhibits maltase and sucrase, and, to a lesser extent, pancreatic lipase in a concentration-dependent manner.
These results suggest that CPP modulates whole-body substrate oxidation by suppressing postprandial hyperglycaemia and hyperinsulinaemia, and these effects are mediated by inhibiting digestive enzymes.
Source: Coffee polyphenols modulate whole-body substrate oxidation and suppress postprandial hyperglycaemia, hyperinsulinaemia and hyperlipidaemia
As the regular readers or subscribers know, I've covered a number of coffee studies in the last few months. For further reading, here are some other studies I've covered on coffee:
- potentially inhibiting some breast cancers
- preventing prostate cancer
- protecting DNA from free-radical damage and assisting in weight loss
- reducing the risk of brain tumours (many studies covered in this post... you'll find this study about halfway down)