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2011-07-18

Alpha-Lipoic Acid Reduces Drug-Induced Oxidative Stress

Ok, so this was just a study on rats, but I think it's still of interest. Well, it's not even something "new" since we already know that alpha-lipoic acid (ALA) is a great antioxidant, but what's interesting about this one is that the oxidation in the test subjects was induced by the antipsychotic drug, haloperidol.

Haloperidol in known to significantly decrease levels of the antioxidant enzymes, superoxide dismutase and glutathione peroxidase in the brain. In this study, ALA administration was found to significantly reduced the oxidative effects of haloperidol in the brain.

The authors state, "...the study proves that alpha lipoic acid treatment significantly reduces haloperidol-induced neuronal damage."

I've said this before for ALA products... just make sure your healthfood retailer is selling them from the fridge as ALA is not very stable at room temperature. The exception being if it's "stabilized" ALA (would be stated on the label, or identified by looking for the sodium salt of ALA in the ingredient list).


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