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Ubiquinol (Reduced CoQ10) Lowers Cholesterol Levels

Another study adding to the small, yet growing database of human clinical trials for ubiquinol -- the antioxidant form of CoQ10.

In this study, 150 mg/day was able to decrease LDL ("bad" cholesterol) levels by 12.7% in only 2 weeks! Further, the effect was most pronounced in the small, dense LDL particles, which have a greater impact on atherosclerosis (plaque formation) than other types of LDL cholesterol.

In addition, induction of gene expression patterns involved in inflammation, cellular differentiation and death were observed (suggesting possible mechanisms for CoQ10's observed anti-cancer effects).

While this is a great study, it had a relatively small sample size and no control group. Even though this is typical for "pilot" studies, I would love to see the next step be a randomized, double-blinded, placebo-controlled clinical trial.

Nonetheless, my experience with ubiquinol has been nothing short of amazing, and anecdotal reports all over the world are suggesting that this is the form of CoQ10 people would get the most therapeutic benefit from.

One last thing I should point out... ubiquinol (but not CoQ10 as ubiquinone) is considered an extremely powerful antioxidant. Why is this important? LDL cholesterol is usually not a problem until it becomes oxidized. By preventing its oxidation (with ubiquinol), even if LDL is present in amounts greater than desired, you essentially neutralize its potential harmful, plaque-forming abilities.

If you're looking to buy a ubiquinol product, just make sure you buy from a reputable brand that guarantees its stability (as ubiquinol is an unstable molecule).

Other posts discussing new CoQ10 studies:

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Source: Ubiquinol-induced gene expression signatures are translated into altered parameters of erythropoiesis and reduced low density lipoprotein cholesterol levels in humans


  1. Seems like this is what I need.
    I am going to take it before I
    am getting worse my condition.
    Thank you Dr. Know.

  2. Hi Dr. Know,

    Can you tell me if CoQ10 (as ubiquinone)can lower cholesterol levels? I've been trying to research this but can't find an answer. Perhaps your research or resources will find what I couldn't?

    Thanks for your help and keep up the good work with this blog.

  3. Hi Ken,

    That's an excellent question, because prior to seeing this study, I didn't think of CoQ10 for cholesterol at all. CoQ10 is obviously great if you're taking statin medications to treat cholesterol, but not to treat cholesterol directly. I've been asked this multiple times since posting the study, so I'm glad you posted a question...this way I can reply for everyone interested.

    I did a search to see what studies on CoQ10 were done for cholesterol reduction, and all I could find were 4. Keep in mind that all the following were done using standard CoQ10 (ubiquinone). Here's the summary in reverse chronological order...

    2005 by Cicero et al. --> 150 mg/day for 6 weeks found no effect

    1999 by Henriksen et al. --> 100 mg/day for 12 weeks found no effect

    1999 by Singh & Niaz --> 120 mg/day for 4 weeks found no effect

    1994 by Digiesi et al. --> 100 mg/day for 10 weeks found a 4.3% reduction in LDL

    So overall, the totality of evidence suggests standard CoQ10 is not effective for cholesterol reduction.

    Personally, I'd love to see a second study on ubiquinol to confirm the effects.

    In the meantime, if you've got cholesterol issues, my "gold standard" therapy with a 95+ percent success rate is... :)

  4. According to the paper: "A significant reduction of LDL cholesterol levels was found in serum samples of study subjects (from 95.51 ± 28.89 mg/dL to 90.60 ± 27.21 mg/dL, P = 0.022). On the basis of 1H NMR analysis, Q10H2 supplementation shows significant reductions of LDL cholesterol of ∼12.71% (P = 1.21E-07)."

    So how does going from 95.5 to 90.6 equate to 12.7% Looks more like 5% to me.

  5. First Amendment, what a great observation! Someone's math is definitely off there.

    The only thing I can think of is NMR, which can actually measure the amounts of the different types of cholesterol particles, gave different results than the typical lab results (in which case the manner in which the results were presented needs to be amended).

  6. my personal exsperience is that my cholesterol levels total droppe3d to 2 from 6 in about 3mnths of taking 100mgs of ubiquinol per day .you could feel the body burning fat my body felt hot .as i understand its used in the mitrochondria to burn cholesterol

  7. Cholesterol is a type of fat found in your blood....Your liver makes cholesterol for your body... This Coenzyme Q10 is a substance that works similar to vitamins. Your body manufactures CoQ10, which it uses to make proteins, contract muscles and provide energy for your cells..Amazing post..!!



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